340+
Companies
From radiology to autonomous data ops, SpireRise founders are turning AI from a feature into entire categories. Here's who they are.
An autonomous data-operations layer that keeps enterprise pipelines clean and self-healing. Started at SpireRise Cohort 04 as two engineers and a notebook; now a Series B company serving Fortune 100 data teams.
FDA-cleared models flagging missed findings across 9 hospital networks.
SynthAnswering calls and booking jobs for 12,000 local businesses.
Forge AIAutonomous incident response for cloud infrastructure teams.
NimbusHyperlocal climate forecasting for insurers and farmers.
QuantaLLM tooling for systematic trading desks.
HelixGenerative models for novel therapeutic candidates.
OrbitResolving 60% of tickets end-to-end for SaaS companies.
ParallaxGenerative pipelines for game and film studios.
NorthwindReinforcement learning that balances renewable energy loads.
The largest slice, where AI is replacing entire workflows for large organizations.
Healthcare, fintech, legal and climate teams owning a specific industry end to end.
The picks and shovels: eval, serving, orchestration and data tooling.
New interfaces and creative tools reaching people directly.
"Being in a room of AI-native founders who were one week ahead of us changed our trajectory. We borrowed every lesson the day they learned it."
"Seeing peers one step ahead made every hard call obvious. We stopped guessing."
"The cohort became our first board, our first users and our first real fans."
Hubs in SF, NYC and Toronto.
London, Berlin, Stockholm and beyond.
Singapore, Bangalore, Seoul, Tokyo.
From São Paulo to Lagos to Sydney.
